Synthesis and Biological Evaluation of Furyl-Carboxamide Derivatives as Potential Anticancer Agents

Topoisomerase II (Top-II) is an essential therapeutic target in cancer treatment owing to its overexpression a wide variety of cancerous cells, including colorectal and breast cancer. Significant efforts have been made discover develop competitive inhibitors the Top-II enzyme as potential anticancer agents. Herein, molecular modeling was employed identify new series furyl-2-carboxamide derivatives Compounds 3, 5, 7 were synthesized characterized with aid several spectroscopic techniques, such FT-IR, NMR, mass spectroscopy, well elemental analysis. The activity properties compounds evaluated vitro using MTT assay human HCT-116 cell line different concentration dilutions. results indicate that anthraquinone compound 3 1.3-1.6 times more potent against colon cells than pyridine benzophenone respectively, which reveals importance moiety exerting inhibitory compound. Our findings recommend further optimization this would benefit treatment.